Tutorial Instructions

Searchable Questions

About MEDLINE

Keyword/Textword

Searching

Medical Subject Headings

Overview 1

Mapping

Subheadings

MeSH Tree

Explode

Focus

Combining (AND, OR)

Combining Overview

Limiting

Displaying Results

Full Text Articles

Printing/E-Mailing/Saving

Ordering Articles

This is the COMPLETE REFERENCE.

	Search Results
Ask a Librarian

Results of your search: *Estrogen Replacement Therapy/

Viewing 2 of 5252 Results

Go to #:

If you want to select this article for printing or saving, you could click in the checkbox (beside Result 2.) before going on to the next result or returning to the main search page. Scroll down the screen to review the various citation fields and options that are available in a complete reference.

---

Result 2.

|

Link to...

Unique Identifier	16193292
Record Owner	NLM
Authors	Godsland IF.
Authors Full Name	Godsland, I F.
Institution	Department of Endocrinology and Metabolic Medicine, Imperial College London, St Mary's Hospital, UK. i.godsland@imperial.ac.uk
Title	Oestrogens and insulin secretion. [Review] [50 refs]
Source	Diabetologia. 48(11):2213-20, 2005 Nov.
Abbreviated Source	Diabetologia. 48(11):2213-20, 2005 Nov.
NLM Journal Name	Diabetologia.
Publishing Model	Journal available in: Print-Electronic Citation processed from: Print
NLM Journal Code	e93, 0006777
Journal Subset	IM
Local Messages	Alumni Medical Library owns some volumes. Check "Library Holdings" for details.
Country of Publication	Germany
MeSH Subject Headings	Animals Carbohydrate Metabolism *Diabetes Mellitus / ep [Epidemiology] Diabetes Mellitus / me [Metabolism] Diabetes Mellitus, Experimental / dt [Drug Therapy] *Estrogen Replacement Therapy *Estrogens / me [Metabolism] Estrogens / pd [Pharmacology] *Estrogens / tu [Therapeutic Use] Female Humans Incidence *Insulin / se [Secretion] Insulin Resistance Insulin-Secreting Cells / se [Secretion] Postmenopause Prevalence Research Support, Non-U.S. Gov't
During a live OVID session, you can click on any of the MeSH above to find articles on the same topic(s). Examining the MeSH is a good way to find clues to improve your search results. Often, you'll discover useful MeSH headings that can be incorporated into your search.
Abstract	There is a persistent perception that oestrogens have an adverse effect on carbohydrate metabolism. It might therefore be expected that their use would result in a corresponding increase in the incidence of diabetes. Recent evidence from clinical trials suggesting that women on postmenopausal oestrogen hormone replacement therapy (HRT) have a reduced incidence of type 2 diabetes therefore appears paradoxical. Short-term supraphysiological oestrogen administration has an adverse effect on glucose tolerance, resulting from suppression of first-phase insulin secretion and increased insulin resistance. Oestrogen-induced increases in glucocorticoid activity could account for these effects. Oestrogen-induced deterioration in glucose tolerance is, however, accompanied by a reduction in fasting glucose, an effect that could be accounted for by glucagon antagonism. These short-term effects contrast with long-term preservation of insulin secretion and glucose homeostasis by oestrogens. In animal studies, ovariectomy is associated with decreased insulin secretion and increased risk of diabetes, whereas oestrogen administration protects against diabetes and increases the insulin response to glucose. The mechanism is uncertain, but direct effects on the pancreas via steroid receptors or indirect effects via oestrogen-induced glucagon antagonism and subclinical increases in glucocorticoids and growth hormone could all contribute. Recent evidence that HRT increases the risk of cardiovascular disease suggests that it should not be used for the prevention of diabetes, but the mechanism responsible for this benefit merits further investigation and might lead to new therapies. [References: 50]
CAS Registry/EC Number/Name of Substance	0 (Estrogens). 11061-68-0 (Insulin).
ISSN Print	0012-186X
Publication Type	Journal Article. Review.
Language	English
Electronic Date of Publication	20050929
Date of Publication	2005 Nov
Entry Date	20060126
Update Date	20060127

Now let's move on to the FULL TEXT DISPLAY options.

---